Acetylcholine activates two currents in guinea-pig outer hair cells.
نویسندگان
چکیده
منابع مشابه
Inhibition of K+ currents of outer hair cells in guinea pig cochlea by fluoxetine.
The effects of fluoxetine (Prozac), a widely used antidepressant drug, on K+ channel in outer hair cells isolated from guinea pig cochlea were studied using the whole-cell patch clamp technique. Fluoxetine potently inhibited leak K+ currents with an IC50 of 0.78 microM. The inhibition was reversible and voltage-independent. At 45- to 103-fold higher concentrations than the plasma levels, fluoxe...
متن کاملTwo types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea.
Cell-attached and cell-free configurations of the patch-clamp technique were used to investigate the conductive properties and regulation of the major K+channels in the basolateral membrane of outer hair cells freshly isolated from the guinea pig cochlea. There were two major voltage-dependent K+ channels. A Ca2+-activated K+ channel with a high conductance (220 pS, P K/ P Na= 8) was found in a...
متن کاملTwo types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea
Van Den Abbeele, Thierry, Jacques Teulon, and Patrice Tran Ba Huy. Two types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea. Am. J. Physiol. 277 (Cell Physiol. 46): C913–C925, 1999.— Cell-attached and cell-free configurations of the patch-clamp technique were used to investigate the conductive properties and regulation of the major K1 channels in the bas...
متن کاملInhibition of potassium currents in outer hair cells and Deiters' cells from guinea pig cochlea by linopirdine.
To study the functional expression of KCNQ gene in outer hair cells (OHCs) and Deiters' cells, the effects of linopirdine on the whole cell K(+) current were investigated by using the whole cell variant of patch clamp technique in the present study. The outward tetraethylammonium (TEA)-sensitive K(+) current and the inward K(+) current (I(Kn)) in OHCs were recorded and measured before and after...
متن کاملAcetylcholine-induced potassium current of guinea pig outer hair cells: its dependence on a calcium influx through nicotinic-like receptors.
The cholinergic efferent inhibition of mammalian outer hair cells (OHCs) is mediated by a hyperpolarizing K+ current. We have made whole-cell tight-seal recordings from single OHCs isolated from the guinea pig cochlea to characterize the mechanism by which acetylcholine (ACh) activates K+ channels. After ACh application, OHCs exhibited a biphasic response: an early depolarizing current precedin...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1996
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1996.sp021240